Covid-19 : Stay Safe Everyone! Take Care!

[Cecil Lee]

We are also

[Cecil Lee]

Let’s be clear… not anti-vax. But seriously all vaccines today are not for real… LOL

Oh dear, 3rd booster, 4th, 5th, 6th, 7th?

Only if put a gun against….. my… head LOL

[Cecil Lee]

O’dear….Here it goes again…

https://www.asiaone.com/singapore/covid-19-booster-shots-be-administered-5-months-after-second-dose-all-age-groups-ong-ye

What’s next yet after another 5 months ?

Don’t tell us.. we already knew…

[Cecil Lee]

Source and credit, as shown…

[Cecil Lee]

MOH’s infatuation with mRNA…LOL

mRNA? Time will be the judge of it. 

On 29 December 2021 @ Raffles Hospital, 3rd Sinopham compulsory booster...LOL Bring it on....

Stay Safe!

[Cecil Lee]

Let's hope the person should be able to get at least ONE FREE!

Select your FREE gift:

A = A whole roasted Spring Chicken or

B = $100/- Hawker food vouchers or

C = 3 Packets of Roasted Premium Nuts + 3 cans of Red Bull drinks.

You must show proof of your identity card before collecting your FREE gift.

If you have already kaput, too bad, you are not allowed to transfer your credit to others!

[Cecil Lee]

Bring it on man/madam.... 

My hands may look like a junkie's! But at least I live to tell the tale... LOL
Never mind, I don't need FREE ones....

No choice, only need to Pay And Pay for it....

[Cecil Lee]

MOH “ We like… the more the better do it the better so that our statistics look really good!” LOL

 

[Cecil Lee]

[Cecil Lee]

From 29 March 2022 onwards

[Cecil Lee]

Source and Credit:-

Traditional vaccines like Sinovac may prevent severe disease in Covid-19 patients: Study | The Straits Times

The Straits Times 
PUBLISHED 

14 NOV 2022, 5:00 AM SGT

Traditional vaccines like Sinovac may prevent severe disease in Covid-19 patients: Study

SINGAPORE - Though often considered inferior due to their induction of a lower antibody response compared with their mRNA counterparts, inactivated virus vaccines can play a role in preventing the development of severe Covid-19, a recent study has found.

This could mean that a combination of the two vaccine types may offer better protection against the coronavirus, researchers said, noting each had its own advantages.

The study by the Duke-NUS Medical School found that inactivated virus vaccines such as Sinopharm and Sinovac, which were used extensively in Asia, and mRNA vaccines – which include Pfizer-BioNTech’s Comirnaty and Moderna’s Spikevax – trigger different T-cell responses in fighting the coronavirus.
 

Inactivated vaccines - an older technology used in the polio and influenza vaccines, among others - are made up of dead viruses, unlike mRNA vaccines, which use just parts of the virus’ genetic material to stimulate an immune response.

While mRNA vaccines induce T-cells – a type of white blood cell – targeting the spike protein of the coronavirus, inactivated vaccines elicit a broader immune response against different proteins on the virus. 

This means that while inactivated vaccines might not be as good at preventing Covid-19 infection, they can play a role in preventing the development of severe disease, said the study’s senior co-author Anthony Tanoto Tan, a senior research fellow with the Duke-NUS’ Emerging Infectious Diseases programme.
Earlier studies had shown that mRNA vaccines help patients produce a far greater number of antibodies, compared with their inactivated virus counterparts. However, newer variants have proved to be more adept at evading the antibody response, Dr Tan said.

“This means that maybe we should stop thinking about preventing infection, and we should start thinking about (how) vaccines (can prevent) severe disease,” he said.  

The research team compared the T-cell immune response in about 500 blood samples from more than 130 people who received inactivated Sars-CoV-2 and spike mRNA vaccines. 

The study, which was published in medical journal Cell Reports Medicine in October, found that mRNA vaccines can induce T-cells targeting SARS-CoV-2’s spike protein, which contains numerous mutations in the Omicron variant. 

However, inactivated vaccines stimulated a broad T-cell response not only against the virus’ spike protein but also the membrane and nucleoprotein, which have much fewer mutations in the Omicron variant. 

Unlike the mRNA vaccines, the inactivated vaccines did not seem to generate cytotoxic CD8 cells – T-cells known for their ability to kill virus-infected cells. Instead, they mainly stimulated a type of T-cell called CD4, or “helper” T-cells. When these helper cells recognise a viral antigen, they release cytokines – chemicals that help activate other types of immune cells.

The broader response provided by inactivated vaccines, in generating T-cell responses towards other viral proteins, could be beneficial, said the study’s senior author, Professor Antonio Bertoletti, from Duke-NUS’ Emerging Infectious Diseases programme.

Larger studies are needed to clarify the impact of these T-cells’ responses to better design vaccines for controlling severe Covid-19, he said.

This does not mean that inactivated vaccines are superior to mRNA or other vaccine technologies, Dr Tan told The Straits Times.

The question of which of the different vaccines – all of which were developed after a significant amount of research – is “better” is not straightforward, he said. “They all have their advantages.”

However, a different vaccination strategy may be required, Dr Tan said, suggesting that one possible approach could be that a person gets the primary series of vaccination with an mRNA vaccine and subsequently get a booster using an inactivated virus alternative to get the best of both worlds.

ST reported in October 2021 that private clinics here were seeing significant demand for Sinopharm and Sinovac boosters among patients who had previously taken mRNA jabs, which was attributed to a fear of side effects.

Experts, however, noted at the time that inactivated vaccines had not yet been proven to have a better response as boosters, compared with other vaccines.

The study adds important insight to our understanding of immunity against the coronavirus, said Dr Leong Hoe Nam, an infectious diseases expert at Mount Elizabeth Novena Specialist Centre.

However, it may not be beneficial for patients to take an inactivated vaccine as a booster, after taking an mRNA vaccine during their primary series, he said.

This is because the strong immune response conferred by an mRNA vaccine may negate any advantages from the inactivated vaccine, said Dr Leong, adding that there are no studies regarding the benefits of taking the vaccines in such an order.

The Duke-NUS research team called for further research with more participants, to better compare the ability of the cell response induced by inactivated virus vaccines with that of the mRNA vaccines in reducing the severity of Covid-19 infection.

Source and Credit:-

Traditional vaccines like Sinovac may prevent severe disease in Covid-19 patients: Study | The Straits Times

[Cecil Lee]

Who's laughing now?

[Cecil Lee]

The bane of COVID 19
Beginning of Year 2023

Singapore news! Everyone is advised to wear a mask because the new COVID-Omicron XBB variant coronavirus is different, deadly and not easily detected properly:-

Symptoms of the XBB virus are as follows:

     1. No cough.
     2. No fever.

     There will only be:

     3. Joint pain.
     4. Headache.
     5. Neck pain.
     6. Upper back pain.
     7. Pneumonia.
     8. General loss of appetite.

 XBB is 5 times more toxic than Delta variant and has a higher mortality rate.  It takes a shorter time for the condition to reach extreme severity, and sometimes there are no obvious symptoms.

This strain of the virus is not found in the nasopharyngeal region, and it directly affects the lungs, the "windows," for a relatively short period of time.

Nasal swab tests are generally negative for COVID-Omicron XBB, and false-negative cases of nasopharyngeal tests are increasing. This means the virus can spread in the community and directly infect lungs, leading to viral pneumonia, which in turn causes acute respiratory stress.

 XBB has become highly contagious, highly virulent and lethal.

Avoid crowded places, keep a distance of 1.5m even in open spaces, wear a double-layer mask, wear a suitable mask, wash hands frequently even when everyone is asymptomatic (no coughing or sneezing).

Don't keep this information to yourself, share as much as possible with other relatives and friends, especially yours.

[Cecil Lee]

Source & Credit:

[Cecil Lee]

A Dr’s speech 
https://www.bitchute.com/video/P0AMsMwDJsrv/